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Monalizumab Biosimilar - Research Grade

Product Specifications

Background

RUO monalizumab is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. By acting simultaneously on innate and adaptive immunity, monalizumab may re-establish a broad anti-tumor response.

Specifications

Detects human CD159a. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Monalizumab.

Product Name Alternative

KLRC1,NKG2A,CD159a,CD94

UniProt

P26715

Species Reactivity

Human

Target

NKG2A

Isotype

IgG4

Applications

Functional Assays

Purification Method

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Concentration

5mg/mL

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>95% by SDS-PAGE

Buffer

ICH3002

Shipping Conditions

Blue ice

Storage Conditions

This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.

Formulation

Sterile, preservative-free, solution in PBS. BSA and Azide free.

Applications Notes

This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

Isotype Control

https://ichor.bio/product/bulk-human-igg4-isotype-control-ib4-ich2257/

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