Sintilimab Biosimilar - Research Grade

Product Specifications

Background

Pembrolizumab biosimilar is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. It is an IgG4 kappa immunoglobulin with an approximate molecular weight of 149 kDa.

Specifications

Detects human PD-1. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Sintilimab.

Product Name Alternative

Programmed cell death protein 1, Pdcd1, CD279

UniProt

Q15116

Host

Humanized

Species Reactivity

Human

Target

PD-1

Isotype

IgG4

Applications

Functional Assays

Purification Method

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Concentration

1.0 - 5.0 mg/mL

Endotoxin

<1EU/mg Determined by LAL gel clotting assay

Purity

>95% by SDS-PAGE and HPLC

Buffer

ICH3002

Shipping Conditions

Blue ice

Storage Conditions

Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.