Bulk anti-Human CXCR4 (12G5) Antibody
Product Specifications
Background
12G5 binds specifically to both human and nonhuman cells that express recombinant CXCR4. 12G5 inhibits CD4-independent infection by some HIV-2 isolates, and preincubating cells with 12G5 abolishes syncytium formation. HIV-2/vcp-infected cells display a marked and selective reduction in 12G5 binding. 12G5 also inhibits induction of cell-to-cell fusion of CXCR4+ RD/CD4 cells by HIV-1 and HIV-2 strains.
CAS Number
9007-83-4
Specifications
12G5 activity is directed against human CXCR4 (CD184; Fusin)
Product Name Alternative
Fusin, LESTR, CD184
Host
Mouse
Species Reactivity
Human
Target
CXCR4
Isotype
IgG2a Kappa
Clone
12G5
Applications
Blocking, Flow Cytometry, Immunocytochemistry, Immunofluorescence Microscopy, Immunohistochemistry, Neutralization, Western Blotting
Purification Method
This monoclonal antibody was purified using Protein A
Concentration
≥ 2.0 mg/mL
Endotoxin
<1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE
Buffer
ICH3001-100mL ICH3002-100mL ICH3003-100mL
Shipping Conditions
Blue ice
Storage Conditions
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation
Sterile, preservative-free, solution in PBS. BSA and Azide free.
Antigen Distribution
CXCR4 is expressed in various organs including ovary, bone marrow, kidney, lung, small intestine, spleen, lymph nodes, brain, stomach, liver, thymus, heart, and pancreas as well as on the surface of endothelial mature and precursor cells and pericytes.
Aggregation
Aggregation level ≤ 5%
Applications Notes
Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control
https://ichor.bio/product/mouse-igg2a-in-vivo-isotype-control-low-endotoxin-c1-18-4-ich2245/
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