Anti-Mouse LAG-3 (C9B7W) In Vivo Antibody - Low Endotoxin
Product Specifications
Background
LAG-3, also known as CD223, is 70 kD type I transmembrane glycoprotein within the Ig superfamily. CD223, like CD4, binds MHC class II molecules, but with higher affinity than CD4. Clone C9B7W antibody has been reported to block the function of murine LAG-3 in vivo and in vitro.
CAS Number
9007-83-4
Specifications
Anti-LAG-3 In Vivo Antibody - Low Endotoxin (C9B7W) recognizes an epitope on Mouse LAG-3
Product Name Alternative
Lymphocyte activation gene 3 protein, Aida, CD223
UniProt
Q61790
Host
Rat
Species Reactivity
Mouse
Target
LAG3
Isotype
IgG1 Kappa
Clone
C9B7W
Applications
Western Blot, Blocking, Flow Cytometry, Immunoprecipitation, ELISA
Purification Method
This monoclonal antibody was purified using Protein G
Concentration
1.0 - 5.0 mg/mL
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE and HPLC
Buffer
ICH3001-100mL ICH3002-100mL ICH3003-100mL
Shipping Conditions
Blue ice
Storage Conditions
Anti-LAG-3 In Vivo Antibody - Low Endotoxin (C9B7W) is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation
0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Antigen Distribution
T-cells and NK cells
Aggregation
Aggregation level ≤ 5%
Applications Notes
Blocking: Clone C9B7W antibody blocks the function of murine LAG-3 in vivo.
Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control
https://www.ichor.bio/product/Rat-IgG1-Isotype-Control-for-In-Vivo-Low-Endotoxin-GL113-ICH2246
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