Anti-Mouse CD120a (55R-593) In Vivo Antibody - Low Endotoxin

Product Specifications

Background

Tumor Necrosis Factor Receptor Type I (TNFRI) is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-A and TNF-B (also known as LT-A). The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM), IL-6 mRNA accumulation and NF-ĸB induction. TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein). Binding of 55R-170 antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.

CAS Number

9007-83-4

Specifications

Armenian Hamster anti-Mouse CD120A (Clone 55R-593) recognizes Mouse CD120A

Product Name Alternative

Tumor necrosis factor receptor superfamily member 1A, Tnfrsf1a, TNF-R1, TNF-RI, p55, p60, CD120a

UniProt

P25118

Host

Armenian Hamster

Species Reactivity

Mouse

Target

TNF Receptor I

Isotype

IgG1

Clone

55R-593

Applications

Immunoprecipitation, Western Blot

Purification Method

This monoclonal antibody was purified using Protein A

Concentration

1.0 mg/mL

Endotoxin

≤ 1.0 EU/mg as determined by the LAL method

Purity

>95% by SDS-PAGE and HPLC

Buffer

ICH3001-100mL ICH3002-100mL ICH3003-100mL

Shipping Conditions

Blue ice

Storage Conditions

This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C.