Itameline

Itameline (RU 47213) is a prodrug with oral and long-lasting cholinergic activity. Itameline is a novel tetrahydropyridine-oxime that is cleaved in vivo to form an active metabolite, RU 35963. RU 35963 is a muscarinic receptor agonist that is nonselective with respect to receptor subtypes. Itameline possesses the capacity to reduce memory deficits induced by an impairment of cholinergic transmission in the rat[1].

Product Specifications

CAS Number

[145071-44-9]

Product Name Alternative

RU 47213

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/itameline.html

Smiles

O=C(N1CCC=C(/C=N/OC)C1)OC2=CC=C(Cl)C=C2

Molecular Formula

C14H15ClN2O3

Molecular Weight

294.73

References & Citations

[1]M M'Harzi, et al. Ameliorating effects of RU 47213, a novel oral and long-lasting cholinomimetic agent, on working memory impairments in rats. Pharmacol Biochem Behav. 1997 Apr;56 (4) :663-8.