Pregnenolone monosulfate
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
Product Specifications
CAS Number
[1247-64-9]
Product Name Alternative
3β-Hydroxy-5-pregnen-20-one monosulfate
UNSPSC
12352100
Target
Autophagy; Cannabinoid Receptor; Endogenous Metabolite; TRP Channel
Type
Natural Products
Related Pathways
Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Pregnenolone_monosulfate.html
Purity
99.96
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC([C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OS(=O)(O)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
Molecular Formula
C21H32O5S
Molecular Weight
396.54
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
CB1; Human Endogenous Metabolite
Available Sizes
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