Nifekalant (hydrochloride)
Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 μM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research[1][2].
Product Specifications
CAS Number
130656-51-8
Product Name Alternative
MS-551
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nifekalant-hydrochloride.html
Purity
99.92
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H]Cl.O=C1N(C)C(C=C(NCCN(CCO)CCCC2=CC=C([N+]([O-])=O)C=C2)N1C)=O
Molecular Formula
C19H28ClN5O5
Molecular Weight
441.91
Precautions
H302, H315, H319, H335
References & Citations
[1]Lü-Pei Du, et al. The pharmacophore hypotheses of I (Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorg Med Chem Lett. 2004 Sep 20;14 (18) :4771-7.|[2]Ioannis N Pantazopoulos, et al. Nifekalant in the treatment of life-threatening ventricular tachyarrhythmias. World J Cardiol. 2011 Jun 26;3 (6) :169-76.|[3]J Chen, et al. IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats. Br J Pharmacol. 1996 Nov;119 (5) :937-42.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY402477 100 µg
GRIM19 (NDUFA13) (NM_015965) Human Over-expression Lysate
Sign In for Pricing
View Details 