Nifekalant (hydrochloride)

Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 μM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research[1][2].

Product Specifications

CAS Number

[130656-51-8]

Product Name Alternative

MS-551

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nifekalant-hydrochloride.html

Purity

99.92

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H]Cl.O=C1N(C)C(C=C(NCCN(CCO)CCCC2=CC=C([N+]([O-])=O)C=C2)N1C)=O

Molecular Formula

C19H28ClN5O5

Molecular Weight

441.91

Precautions

H302, H315, H319, H335

References & Citations

[1]Lü-Pei Du, et al. The pharmacophore hypotheses of I (Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorg Med Chem Lett. 2004 Sep 20;14 (18) :4771-7.|[2]Ioannis N Pantazopoulos, et al. Nifekalant in the treatment of life-threatening ventricular tachyarrhythmias. World J Cardiol. 2011 Jun 26;3 (6) :169-76.|[3]J Chen, et al. IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats. Br J Pharmacol. 1996 Nov;119 (5) :937-42.