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(Rac) -Hesperetin-d3

(Rac) -Hesperetin-d3 is the deuterium labeled (Rac) -Hesperetin. (Rac) -Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

Product Specifications

CAS Number

1346605-26-2

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Apoptosis; Autophagy; Bcl-2 Family; Isotope-Labeled Compounds; NF-κB; p38 MAPK; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer; Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O)=C(C=C3)OC([2H])([2H])[2H])C1

Molecular Formula

C16H11D3O6

Molecular Weight

305.30

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Arya A, et al. Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:954-964|[3]Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39 (12) :2052-2059.|[4]Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301|[5]Li Q, et al. Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation. Nutr Cancer. 2019 Jul 11:1-8.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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