Segigratinib (hydrochloride)
Segigratinib hydrochloride (3D185) is a potent inhibitor of FGFR1/2/3 and CSF-1R; The IC50 values for FGFR1, FGFR2, FGFR3 and CSF-1R are 0.5, 1.3, 3.6 and 3.8 nM, respectively. Segigratinib hydrochloride has antitumor activity[1].
Product Specifications
CAS Number
2847066-15-1
Product Name Alternative
3D185; HH185
UNSPSC
12352005
Target
C-Fms; FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/segigratinib-hydrochloride.html
Smiles
O=C(C1=CC=C(N2CCNC(C)(C2)C)C=C1)NC3=NNC4=C3C=CC(C5=C(Cl)C(OC)=CC(OC)=C5Cl)=N4.Cl
Molecular Formula
C27H29Cl3N6O3
Molecular Weight
591.92
References & Citations
[1]Peng X, et al. Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models. J Exp Clin Cancer Res. 2019 Aug 22;38 (1) :372.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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