JH-II-127

JH-II-127 is an orally active, highly potent, selective and brain-permeable LRRK2 inhibitor, with IC50s of 6, 2 and 48 nM for wild-type LRRK2 and LRRK2-G2019S and mutant LRRK2-A2016T. JH-II-127 inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be used in the study of parkinson's syndrome[1].

Product Specifications

CAS Number

[1700693-08-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/JH-II-127.html

Purity

98.0

Solubility

DMSO : 110 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(NC2=NC3=NC=C(Cl)C3=C(NC)N2)C(OC)=C1)N4CCOCC4

Molecular Formula

C19H21ClN6O3

Molecular Weight

416.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Hatcher JM, et al. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 2015 Apr 7;6 (5) :584-9.