Detomidine

Detomidine, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine produces dose-dependent analgesic effects[1][2].

Product Specifications

CAS Number

[76631-46-4]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/detomidine.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C)C(CC2=CN=CN2)=CC=C1

Molecular Formula

C12H14N2

Molecular Weight

186.25

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8 (1) :30-7.|[2]J Still, et al. Cardiovascular and respiratory effects of detomidine in isoflurane-anaesthetised horses. J S Afr Vet Assoc. 1996 Dec;67 (4) :199-203.