Flavoxate (hydrochloride)

Flavoxate hydrochloride is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate hydrochloride is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate hydrochloride shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate hydrochloride can be used for the research of overactive bladder (OAB) and lower urinary tract infections[1].

Product Specifications

CAS Number

[3717-88-2]

Product Name Alternative

Rec-7-0040; DW61

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; mAChR; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Flavoxate-hydrochloride.html

Purity

99.70

Solubility

DMSO : 3.33 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C(C(C(C)=C(C3=CC=CC=C3)O2)=O)=CC=C1)OCCN4CCCCC4.Cl

Molecular Formula

C24H26ClNO4

Molecular Weight

427.92

Precautions

H302, H315, H319, H335

References & Citations

[1]Dansette, P.M., et al. HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Exp Toxicol Pathol, 2000. 52 (2) : p. 145-8.|[2]Kimura, Y., et al., Mechanisms of the suppression of the bladder activity by flavoxate. Int J Urol, 1996. 3 (3) : p. 218-27.|[3]Oka, M., et al., Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. Brain Res, 1996. 727 (1-2) : p. 91-8.