URAT1&XO inhibitor 1

URAT1&XO inhibitor 1 (compound 29) is a dual inhibitor of both URAT1 (IC50=~10 μM) and Xanthine Oxidase (IC50=1.01 μM) . URAT1&XO inhibitor 1 results hypouricemic effect in potassium oxonate-induced hyperuricemia rat model. URAT1&XO inhibitor 1 is used for hyperuricemia research[1].

Product Specifications

CAS Number

[2669726-78-5]

UNSPSC

12352005

Target

URAT1; Xanthine Oxidase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/urat1-xo-inhibitor-1.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=CC(C(C(NC2=C(C(O)=O)N=CS2)=O)=CN3CC4=NC=CC=C4)=C3C=C1

Molecular Formula

C20H13N5O3S

Molecular Weight

403.41

References & Citations

[1]Fengwei Lin, et al. Identification of 5-[5-cyano-1- (pyridin-2-ylmethyl) -1H-indole-3-carboxamido] thiazole-4-carboxylic acid as a promising dual inhibitor of urate transporter 1 and xanthine oxidase. European Journal of Medicinal Chemistry. Volume 257, 5 September 2023, 115532.