Avatrombopag-d8 (hydrochloride)
Avatrombopag-d8 (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride) . Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM) . Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].
Product Specifications
Product Name Alternative
AKR-501-d8 (hydrochloride) ; E5501-d8 (hydrochloride) ; YM477-d8 (hydrochloride)
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Thrombopoietin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5C([2H])([2H])C([2H])([2H])N(C6CCCCC6)C([2H])([2H])C5([2H])[2H])S3)=O)C=C2Cl)CC1)O.Cl
Molecular Formula
C29H27D8Cl3N6O3S2
Molecular Weight
694.16
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Ep-CAM / CD326 (VU-1D9), CF594 conjugate, 0.1mg/mL
HLA-Aw32 & HLA-A25 (MHC I) (CATA-1), CF647 conjugate, 0.1mg/mL
