SPOP Antibody / Speckle-type POZ protein
Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
O43791
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids LHSADQLKTQAVDFINYHASDVLE from the human protein were used as the immunogen for the SPOP antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
Limitations
This SPOP antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SPOP antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Western blot testing of human 1) PC-3, 2) HeLa, 3) HepG2, 4) MOLT4 and 5) K562 cell lysate with SPOP antibody. Predicted molecular weight ~42 kDa.
Documents
Frequently Asked Questions
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