DSG2 Antibody / Desmoglein 2

Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL

UniProt

Q14126

Host

Mouse

Reactivity

Human

Immunogen

E. coli-derived recombinant human protein (amino acids L24-E1020) was used as the immunogen for the DSG2 antibody.

Clonality

Monoclonal

Isotype

IgG1

Clone

2B4D1

Applications

WB, IHC-P

Purity

Antigen affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose

Reconstitution

After reconstitution, the DSG2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This DSG2 antibody is available for research use only.

Storage Conditions

After reconstitution, the DSG2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the DSG2 antibody should be determined by the researcher.

Location

Cytoplasm, membrane (cell junctions)

Image Legend

IHC staining of FFPE human breast cancer tissue with DSG2 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.