HDKIR Antibody / C3IP1 / KLHL12
Kelch-like protein 12, also called CUL3-interacting protein 1 (C3IP1) and DKIR homolog (hDKIR), is a protein that in humans is encoded by the KLHL12 gene. This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL
UniProt
Q53G59
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
E. coli-derived recombinant human protein (amino acids R27-I331) was used as the immunogen for the hDKIR antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
2G11D1
Applications
WB, IHC-P
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
Limitations
This hDKIR antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the hDKIR antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
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