Leukocyte elastase inhibitor Antibody / LEI / SERPINB1 / PI-2

Leukocyte elastase inhibitor (LEI) also known as Serpin B1 and Peptidase inhibitor 2 (PI-2) is a protein that in humans is encoded by the SERPINB1 gene. The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.