Isoastilbin

Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research[1][21][3].

Product Specifications

CAS Number

[54081-48-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Tyrosinase

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/isoastilbin.html

Purity

99.23

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O[C@H]([C@@H]([C@@H](O)[C@H](C)O1)O)[C@]1([H])O[C@H]2[C@@H](C3=CC(O)=C(O)C=C3)OC4=CC(O)=CC(O)=C4C2=O

Molecular Formula

C21H22O11

Molecular Weight

450.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Hong Yu, et al. Protective Roles of Isoastilbin Against Alz heimer's Disease via Nrf2-mediated Antioxidation and anti‑apoptosis. Int J Mol Med. 2019 Mar;43 (3) :1406-1416.|[2] Harlinda Kuspradini, et al. Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extracts. J. Wood Sci., 2009, 55 (4) :308-13.|[3]Batubara, Irmanida, et al. Anti-acne and Tyrosinase Inhibition Properties of Taxifolin and Some Flavanonol Rhamnosides from Kempas. Wood Research Journal ,2010, 1 (1) :45-9.