Dnmt3a Antibody
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [UniProt]
Product Specifications
UniProt
Q9Y6K1
Host
Mouse
Immunogen
Recombinant human Dnmt3a was used as the immunogen for the Dnmt3a antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
WB
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Dnmt3a antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Dnmt3a antibody is available for research use only.
CAS Number
9007-83-4
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
