BIRC6 Antibody (C-Terminal Region)
Baculoviral IAP repeat-containing protein 6 / APOLLON is an anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q9NR09
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 4810-4844 from human BIRC6 was used as the immunogen for the BIRC6 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the BIRC6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This BIRC6 antibody is available for research use only.
Storage Conditions
Aliquot the BIRC6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
Western blot testing of BIRC6 antibody at 1:1000: Lane 1) huamn SH-SY5Y and 2) HeLa cell lysate. Predicted molecular weight ~530 kDa.
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