ERAB Antibody / HSD17B10 (N-Terminal Region)
ERAB / HSD17B10 functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) . [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:8000
UniProt
Q99714
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 14-48 from human ERAB was used as the immunogen for the ERAB antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ERAB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ERAB antibody is available for research use only.
Storage Conditions
Aliquot the ERAB antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
Frequently Asked Questions
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