IL-11 Antibody (N-Terminal Region)

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed: 2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:<a href=http://www.uniprot.org/citations/12919066 target=_blank>12919066</a>). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. [UniProt]