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CD59 Antibody (Center Region)

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. [UniProt]

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:2000

UniProt

P13987

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 74-110 from human CD59 was used as the immunogen for the CD59 antibody.

Clonality

Polyclonal

Isotype

Ig

Applications

WB

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the CD59 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This CD59 antibody is available for research use only.

Storage Conditions

Aliquot the CD59 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the CD59 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

Western blot testing of CD59 antibody at 1:2000: Lane 1) human HUVEC, 2) BxPC-3, 3) PC-3, 4) breast and 5) placenta lysate. Predicted molecular weight ~14/18-20 kDa (unmodified/glycosylated) .

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