ROS1 Antibody
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:4000
UniProt
P08922
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human ROS1 was used as the immunogen for the ROS1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1843CT776.78.21
Applications
WB
Purity
Protein G purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ROS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ROS1 antibody is available for research use only.
Storage Conditions
Aliquot the ROS1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
Western blot testing of ROS1 antibody at 1:4000 + partial recombinant protein. Predicted molecular weight ~264 kDa.
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
ELISA Kit for Aspartate Aminotransferase (AST)
ELISA Kit for Aspartate Aminotransferase (AST)
ELISA Kit for Aspartate Aminotransferase (AST)