(E/Z) -J147

(E/Z) -J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. (E/Z) -J147 can readily pass the blood brain barrier (BBB) . (E/Z) -J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. (E/Z) -J147 has potential for the treatment of Alzheimer’s disease (AD) [1][2][3].

Product Specifications

CAS Number

[1146963-51-0]

UNSPSC

12352005

Hazard Statement

H302

Target

Dopamine Transporter; Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/J-147.html

Purity

99.80

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F

Molecular Formula

C18H17F3N2O2

Molecular Weight

350.34

Precautions

H302

References & Citations

[1]Wang M, et al. The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23 (2) :524-7.|[2]Chen Q, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One. 2011;6 (12) :e27865.|[3]Prior M, et al. Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery. Alzheimers Dement. 2016 Jun;12 (6) :678-86.|[4]Prior M, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5 (3) :25.