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Dihydrocoumarin

Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively[1].

Product Specifications

CAS Number

[119-84-6]

Product Name Alternative

Hydrocoumarin; Chroman-2-one

UNSPSC

12352005

Hazard Statement

H302, H317

Target

Sirtuin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Dihydrocoumarin.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1CCC2=CC=CC=C2O1

Molecular Formula

C9H8O2

Molecular Weight

148.16

Precautions

H302, H317

References & Citations

[1]Olaharski AJ, et al. The flavoring agent Dihydrocoumarin reverses epigenetic silencing and inhibits sirtuindeacetylases. PLoS Genet. 2005 Dec;1 (6) :e77.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

SIRT1; SIRT2

Available Sizes

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