Dihydrocoumarin
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively[1].
Product Specifications
CAS Number
[119-84-6]
Product Name Alternative
Hydrocoumarin; Chroman-2-one
UNSPSC
12352005
Hazard Statement
H302, H317
Target
Sirtuin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dihydrocoumarin.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1CCC2=CC=CC=C2O1
Molecular Formula
C9H8O2
Molecular Weight
148.16
Precautions
H302, H317
References & Citations
[1]Olaharski AJ, et al. The flavoring agent Dihydrocoumarin reverses epigenetic silencing and inhibits sirtuindeacetylases. PLoS Genet. 2005 Dec;1 (6) :e77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2
Available Sizes
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