KTX-Sp2

KTX-Sp2 is a potassium channel toxin. KTX-Sp2 effectively blocks three types of exogenous voltage-gated potassium channels: Kv1.1, Kv1.2 and Kv1.3. Ktx-Sp2 inhibits endogenous Kv1.3 and suppresses Ca2+ signaling in Jurkat T cells. Ktx-Sp2 inhibits IL-2 secretion from activated Jurkat T cells[1].

Product Specifications

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ktx-sp2.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)CO)N1[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H]3CCCCN)=O)=O)CC4=CNC=N4)=O)[C@@H](C)O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)CCCNC(N)=N)=O)CSSC[C@H](NC6=O)C(N[C@H](C(NCC(O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)CCC2)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)CSSC[C@H](NC8=O)C(N[C@H]6CCCNC(N)=N)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CO)=O)CO)=O)CO)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]8CCCNC(N)=N)=O)=O)CC(N)=O)=O)CCSC)=O)=O)CCCCN)=O)C)=O)=O)CC9=CNC=N9)=O)CC(C)C)=O)CCC1