Chicanine
Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity[1].
Product Specifications
CAS Number
[78919-28-5]
UNSPSC
12352005
Target
ERK; IKK; p38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chicanine.html
Purity
99.96
Solubility
DMSO : 18 mg/mL (ultrasonic; warming)
Smiles
OC1=CC=C([C@@H]2O[C@@H](C3=CC=C(OCO4)C4=C3)[C@H](C)[C@@H]2C)C=C1OC
Molecular Formula
C20H22O5
Molecular Weight
342.39
References & Citations
[1]Chicanine, et al. Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways. Eur J Pharmacol. 2014 Feb 5;724:168-74.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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