Toddaculin
Product Specifications
UNSPSC Description
Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].
Target Antigen
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/toddaculin.html
Purity
99.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=C(OC)C(C/C=C(C)\C)=C(OC)C=C2O1
Molecular Weight
274.31
References & Citations
[1]Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46.|[2]Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158.|[3]Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N9359/Toddaculin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N9359/Toddaculin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
4335-12-0
Available Sizes
Curated Selection
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