Toddaculin

Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].

Product Specifications

CAS Number

[4335-12-0]

UNSPSC

12352005

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/toddaculin.html

Purity

99.73

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=C(OC)C(C/C=C(C)\C)=C(OC)C=C2O1

Molecular Formula

C16H18O4

Molecular Weight

274.31

References & Citations

[1]Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19 (8-9) :737-46.|[2]Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10 (5) :e0127158.|[3]Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41 (1) :132-137.