Rb Monoclonal Antibody
Product Specifications
Background
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
CAS Number
9007-83-4
Synonyms
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Host
Mouse
Reactivity
Human
Immunogen
Purified recombinant fragment of human Rb expressed in E. Coli.
Clonality
Monoclonal
Applications
IHC-p, IF, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
Frequently Asked Questions
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