VPP2 Polyclonal Antibody

The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome.

V-type proton ATPase 116 kDa subunit a isoform 2 ;V-ATPase 116 kDa isoform a2;Lysosomal H;+-transporting ATPase V0 subunit a2;TJ6;Vacuolar proton translocating ATPase 116 kDa subunit a isoform