PERK(Phospho Thr981) Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
CAS Number
9007-83-4
Synonyms
Eukaryotic translation initiation factor 2-alpha kinase 3; EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PEK/PERK around the phosphorylation site of Thr981. AA range:947-996
Clonality
Polyclonal
Applications
IF, ICC, WB, IHC-p, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
125147
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
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