MDM2(Phospho Ser186/S188) Polyclonal Antibody
Product Specifications
Background
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
CAS Number
9007-83-4
Synonyms
E3 ubiquitin-protein ligase Mdm2; MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MDM2 around the phosphorylation site of Ser186 and Ser188. AA range:151-200
Clonality
Polyclonal
Applications
IF, ICC, WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
55233
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
