GRK2(Phospho-Tyr86) Polyclonal Antibody
Product Specifications
Background
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
CAS Number
9007-83-4
Synonyms
GRK2 ;Phospho-Tyr86; Beta-adrenergic receptor kinase 1; Beta-ARK-1; EC 2.7.11.15; G-protein coupled receptor kinase 2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human GRK2 (Phospho-Tyr86)
Clonality
Polyclonal
Applications
IHC-p, IF, WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
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