CAN3 Polyclonal Antibody

Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.

Calpain-3 ;EC 3.4.22.54;Calcium-activated neutral proteinase 3;CANP 3;Calpain L3;Calpain p94;Muscle-specific calcium-activated neutral protease 3;New calpain 1;nCL-1