c-Myc(Phospho Ser373) Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
CAS Number
9007-83-4
Synonyms
Myc proto-oncogene protein; MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Ser373. AA range:340-389
Clonality
Polyclonal
Applications
IHC-p, IF, IP, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
48804
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
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