PDE12-IN-3

PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity[1].

Product Specifications

CAS Number

[1803357-22-3]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pde12-in-3.html

Purity

98.02

Solubility

DMSO : 80 mg/mL (ultrasonic)

Smiles

N#CC1=CC2=C(C=C1)C(C3=NC4=CC=C(C(N5C(CO)C(C6=CC=CC=C6)OCC5)=O)C=C4N3C)=CN2

Molecular Formula

C29H25N5O3

Molecular Weight

491.54

References & Citations

[1]Wood ER, et al. The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J Biol Chem. 2015 Aug 7;290 (32) :19681-96.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDE12

Available Sizes

Curated Selection

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