TRAF2(Phospho-Ser11) Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with| and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors| and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs)| and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD| a TNF receptor associated apoptotic signal transducer| ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1| an apoptosis inhibitor possessing ubiquitin ligase activity| can unbiquitinate and induce the degradation of this pro

TRAF2 ;Ser11 ; TNF receptor-associated factor 2; EC 6.3.2.-; E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3