TAK1(Phospho-Ser412) Rabbit Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP)| and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1| this protein forms a kinase complex including TRAF6| MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK| MAP2K4/MKK4| and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
CAS Number
9007-83-4
Synonyms
TAK1 ;Ser412; Mitogen-activated protein kinase kinase kinase 7; EC 2.7.11.25; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized phosho peptide around human TAK1 (Ser412)
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
Frequently Asked Questions
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