SLIB Rabbit Polyclonal Antibody

This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor| known as somatoliberin| which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors| and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism| while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants| at least one of which encodes a preproprotein that is proteolytically processed.