SIAH1 Rabbit Polyclonal Antibody

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease| the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants| some encoding different isoforms and others that have not been fully characterized.