Fms-related Tyrosine Kinase 3 Ligand

<strong>Fms-related Tyrosine Kinase 3 Ligand</strong>_x000D_ <strong>Catalog number:</strong> B2010329_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Fms-related Tyrosine Kinase 3 Ligand expressed in CHO. This protein acts as a cytokine that promotes the generation and differentiation of hematopoietic stem cells and their progenitor cells._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuFlt-3 Ligand; Flt3 ligand; FL; SL cytokine; Flt-3L_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Ling L, Tang X, Huang X, Li J, Wang H, Chen Z. AAV-Vectored Fms-Related_x000D_ Tyrosine Kinase 3 Ligand Inhibits CD34⁺ Progenitor Cell Engraftment_x000D_ in Humanized Mice. J Neuroimmune Pharmacol. 2018 Dec;13(4):541-550._x000D_ _x000D_ 2: Posod A, Wegleiter K, Neubauer V, Urbanek M, Huber E, Kiechl-Kohlendorfer U,_x000D_ Keller M, Griesmaier E. Short-, Mid-, and Long-Term Effect of Granulocyte_x000D_ Colony-Stimulating Factor/Stem Cell Factor and Fms-Related Tyrosine Kinase 3_x000D_ Ligand Evaluated in an In Vivo Model of Hypoxic-Hyperoxic Ischemic Neonatal_x000D_ Brain Injury. Biomed Res Int. 2019 Mar 13;2019:5935279._x000D_ _x000D_ 3: Chen J, Du F, Dang Y, Li X, Qian M, Feng W, Qiao C, Fan D, Nie Y, Wu K, Xia_x000D_ L. Fibroblast Growth Factor 19-Mediated Up-regulation of SYR-Related High-_x000D_ Mobility Group Box 18 Promotes Hepatocellular Carcinoma Metastasis by_x000D_ Transactivating Fibroblast Growth Factor Receptor 4 and Fms-Related Tyrosine_x000D_ Kinase 4. Hepatology. 2020 May;71(5):1712-1731._x000D_ _x000D_ 4: Ramos MI, Perez SG, Aarrass S, Helder B, Broekstra P, Gerlag DM, Reedquist_x000D_ KA, Tak PP, Lebre MC. FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis in_x000D_ rheumatoid arthritis. Arthritis Res Ther. 2013;15(6):R209._x000D_ _x000D_ 5: Li F, Xu Y, Xu X, Xu B, Zhao J, Zhang X. Fms-related_tyrosine kinase 3 ligand_x000D_ promotes proliferation of placenta amnion and chorion mesenchymal stem cells_x000D_ in¬†vitro. Mol Med Rep. 2014 Jul;10(1):322-8._x000D_ _x000D_ 6: Williams P, Basu S, Garcia-Manero G, Hourigan CS, Oetjen KA, Cortes JE,_x000D_ Ravandi F, Jabbour EJ, Al-Hamal Z, Konopleva M, Ning J, Xiao L, Hidalgo Lopez J,_x000D_ Kornblau SM, Andreeff M, Flores W, Bueso-Ramos C, Blando J, Galera P, Calvo KR,_x000D_ Al-Atrash G, Allison JP, Kantarjian HM, Sharma P, Daver NG. The distribution of_x000D_ T-cell subsets and the expression of immune checkpoint receptors and ligands in_x000D_ patients with newly diagnosed and relapsed acute myeloid leukemia. Cancer. 2019_x000D_ May 1;125(9):1470-1481._x000D_ _x000D_ 7: Yang J, Zhang W. New molecular insights into osteosarcoma targeted therapy._x000D_ Curr Opin Oncol. 2013 Jul;25(4):398-406._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/18431239/">8: Huang Y, Ratajczak MZ, Reca R, Xu H, Tanner M, Rezzoug F, Hussain LR, Fugier-_x000D_ Vivier I, Bolli R, Ildstad ST. Fms-related tyrosine kinase 3 expression_x000D_ discriminates hematopoietic stem cells subpopulations with differing_x000D_ engraftment-potential: identifying the most potent combination. Transplantation._x000D_ 2008 Apr 27;85(8):1175-84. </a>_x000D_ _x000D_ <strong>Products Related to Fms-related Tyrosine Kinase 3 Ligand </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>