PPAR alpha(Phospho Ser21) Rabbit Polyclonal Antibody

Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand| the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.|online information:Peroxisome proliferator-activated receptor entry|Belongs to the nuclear hormone receptor family. NR1 subfamily.|Contains 1 nuclear receptor DNA-binding domain.|subunit:Heterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators| leading to a strong increase of transcription of target genes. Also interacts with PPARBP coactivator in vitro. Interacts with AKAP13.|tissue specificity:Skeletal muscle| liver| heart and kidney.|