Phospho PKC theta (Y90) Rabbit Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|cofactor:Magnesium.|The C1 domain| containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B)| is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.|enzyme regulation:Three specific sites; Thr-538 (activation loop of the kinase domain)| Ser-676 (turn motif) and Ser-695 (hydrophobic region)| need to be phosphorylated for its full activation.|PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters| a class of tumor promoters.|This is a calcium-independent| phospholipid-dependent| serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation| but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production.|PTM:Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|Contains 1 AGC-kinase C-terminal domain.|Contains 1 C2 domain.|Contains 1 protein kinase domain.|Contains 2 phorbol-ester/DAG-type zinc fingers.|subunit:Interacts with TXNL2/PICOT.|tissue specificity:Skeletal muscle| megakaryoblastic cells and platelets.|