MYPT1/2(Phospho Ser668/Ser618) Rabbit Polyclonal Antibody
Product Specifications
Background
Regulates myosin phosphatase activity.|PTM:Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage| probably by ATM or ATR.|sequence Contaminating sequence. Potential poly-A sequence.|Contains 6 ANK repeats.|subcellular location:Along actomyosin filaments and stress fibers.|subunit:PP1 comprises a catalytic subunit| PPP1CA| PPP1CB or PPP1CC| and one or several targeting or regulatory subunits. PPP1R12A mediates binding to myosin. Interacts with ARHA and CIT (By similarity). Binds PPP1R12B| ROCK1 and IL16.|
CAS Number
9007-83-4
Synonyms
MYPT1/2 ;Phospho Ser668/Ser618; Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunit
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human MYPT1/2 (Phospho Ser668/Ser618)
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
113300
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
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