Met(Phospho-Tyr1234/1235) Rabbit Polyclonal Antibody
Product Specifications
Background
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide| which has been shown to reduce lung fibrosis. Binding of its ligand| hepatocyte growth factor| induces dimerization and activation of the receptor| which plays a role in cellular survival| embryogenesis| and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma| hepatocellular carcinoma| and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
CAS Number
9007-83-4
Synonyms
Met ;Tyr1234/1235; Hepatocyte growth factor receptor; HGF receptor; EC 2.7.10.1; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized phosho peptide around human Met (Tyr1234 and 1235)
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
