I-TAC Rabbit Polyclonal Antibody

disease:Expressed in a variety of skin disorders| including allergic contact dermatitis| lichen planus and mycosis fungoides.|Chemotactic for interleukin-activated T-cells but not unstimulated T-cells| neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.|induction:By interferon gamma and interferon beta. Induction by IFN-gamma is enhanced by TNF-alpha in monocytes| dermal fibroblasts and endothelial cells| and by IL-1 in astrocytes.|mass spectrometry: PubMed:10233762|online information:CXCL11 entry|Belongs to the intercrine alpha (chemokine CxC) family.|tissue specificity:High levels in peripheral blood leukocytes| pancreas and liver astrocytes. Moderate levels in thymus| spleen and lung. Low levels in placenta| prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.|

I-TAC; C-X-C motif chemokine 11; Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11